Senior Principal Scientist, Immunology In Vivo Pharmacology – Bristol Myers Squibb
Job Overview
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Date PostedSeptember 4, 2025
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Location
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Expiration dateOctober 4, 2025
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Click to apply:
Job Description
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
The Immunology and Cardiovascular Thematic Research Center (ICV TRC) at BMS is one of the fundamental Research units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS’s internal invention engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities.

Position Summary:
We are seeking an accomplished and visionary Senior Principal Scientist or Associate Director to lead our Immunology in vivo Pharmacology team and drive the in vivo strategy supporting Immunology programs at all stages, from discovery through development. This leadership role is critical to advancing our portfolio and ensuring robust scientific support for candidate selection, human dose projection, biomarker identification, and life cycle management.
Position Responsibilities:
In the role as a Senior Principal Scientist within Discovery Immunology In Vivo Pharmacology, the ideal candidate:
- Lead and mentor the Immunology in vivo Pharmacology team, providing scientific and strategic direction.
- Identify and implement appropriate PK/PD and disease models to support clinical candidate selection, human dose projection, biomarker identification, and life cycle management.
- Design and oversee in vivo and ex vivo studies to assess target engagement and pharmacodynamic endpoints.
- Contribute to portfolio strategy discussions and foster external collaborations to advance program objectives.
- Communicate scientific findings effectively across multidisciplinary teams and to leadership.
Experience =
Basic Qualifications:
- Bachelor’s Degree
- 10+ years of academic and / or industry experience Or
- Master’s Degree
- 8+ years of academic and / or industry experience Or
- Ph.D. or equivalent advanced degree in the Life Sciences
- 6+ years of academic and / or industry experience
- 2+ years of leadership experience
Preferred Qualifications:
- PhD in a relevant discipline with a minimum of 10 years of post-PhD experience.
- Extensive industry research experience within the Pharmaceutical/Biotechnology sector is highly desirable.
- Demonstrated experience supporting portfolio strategy discussions and managing external collaborations.
- Deep knowledge of the Immunology/Inflammation therapeutic area, with a strong in vivo background.
- Prior hands-on experience with animal models of autoimmune diseases is highly desirable.
- Comprehensive understanding of PK/PD assessments and proven experience designing ex vivo studies for pharmacodynamic and target engagement endpoints.
- Strong scientific and managerial skills, with a proven track record of leadership, collaboration, and excellent communication.
- Publication record in peer-reviewed journals.
If you are a driven scientific leader with a passion for advancing immunology research and a commitment to excellence, we invite you to apply and join our team in making a meaningful impact on patient lives.
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