Job Description

The project

mRNA is an extraordinary opportunity to provide vaccines and therapies in a record time and at the right cost and place.

Such a fast-to-develop technology should go with a fast-to-scale manufacturing process, offering highly flexible capacity.

For meeting such requirements, Dillico is developing a continuous, digitized and scale-up-free GMP mRNA manufacturing equipment.

Responsibilities

As part of the Process Development team, the mRNA-LNP Senior Process Development Scientist will work on the development of the mRNA SP-TFF (Single-Pass Tangential Flow Filtration) purification process and the following LNP encapsulation & purification process.

More precisely, the role includes:

– Set up purification Single-Pass TFF, LNP encapsulation and formulation Single-Pass TFF experiments

– Define process development strategy – Design & perform associated experiment

– Compile experimental and analytical results, perform data interpretation, summarize, and report on data with conclusions and recommended next steps

– Propose improvements and innovative solutions

– Maintain thorough electronic lab notebooks and documentation records

– Establish process control strategy

– Support mRNA drug substance and drug product process development activities for our partners / customers

– Communicate findings internally and externally through meeting with partners and at conferences

– Collaborate with the Modeling, Analytical, Process Engineers and Automation people to transfer the developed process units to the GMP-like pilot

Profile and experience

The successful candidate will have significant experience in large-molecule purification process development, in particular in (single-pass) tangential flow filtration and/or in mRNA encapsulation development.

– PhD or Postdoc or experienced R&D scientist (MS) with proven experience in (single-pass) TFF and mRNA LNP encapsulation

– Experience in purification chromatography and LNP analytical development would be a plus

– 2-5 years of experience (PhD) or 8-10 years of experience (MS) in an industrial setting

– Proven experience in DoE, multivariate analysis and quality-by-design

– Exceptional experimental & analytical skills

– Innovative mindset, team player who fosters collaboration

– Strong communication and collaboration skills, and examples of leadership in process development.

– Knowledge in scale-down model development and process characterization.

– Ability to manage multiple projects in a fast-paced environment and experience managing direct reports

– Proactive, eager to learn, agile and curious about startup and deeptech environments

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Job located in the Grenoble area, France, one of the major high-tech hubs in Europe

Please, Apply to hr@dillico.com or via LinkedIn

What we offer:

A unique opportunity to take part of the development of a start-up where your contribution will be key to the success of the project.

You will be able to grow your career by working in a state-of-the-art innovative environment where you will explore and innovate while working with diverse clients, teams, academic and leaders in the field.

You will be empowered to take important technical and business decisions while working with a great team of experts.

Attractive work conditions:

– Stimulating work environment: multicultural and motivated team

– Live and work close to the Alps

– Lunch vouchers

– 50% of local transportation costs paid

– 5 weeks of holidays per year + 2 weeks of compensation time (RTT)

– Industry-leading healthcare

– Opportunities to network and connect with worldwide experts (clusters)