Job Description

new postdoc position in my lab with anyone who may be a fit. Thank you!

Postdoctoral position: CNS delivery of nucleic acid therapeutics using brain-penetrant bispecific antibodies.

The Tessier Lab (University of Michigan, https://lnkd.in/ezKqi9Yf) has an open postdoctoral position focused on the development and evaluation of bispecific antibodies (“brain shuttles”) designed to deliver therapeutic payloads to the CNS.

This project involves the evaluation of pharmacokinetics, biodistribution, and efficacy of CNS-targeted bispecific antibodies. These antibodies are engineered to deliver nucleic acid payloads, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA), across the blood-brain barrier (BBB). The work builds upon our recent reports of brain shuttles that target the transferrin receptor (TfR-1) and CD98hc, which demonstrate efficient delivery to the brain parenchyma:
1. Pornnoppadol et al., Cell Chem Biol, 2024 (https://lnkd.in/gyXfhuzN)
2. Veire et al., ACS Chem Neurosci, 2025 (https://lnkd.in/gYy2a-sv)

Our brain shuttles offer unique advantages that serve as the foundation for these open projects: TfR-1 shuttles provide fast and maximal brain uptake, while CD98hc shuttles exhibit extended brain retention. As the field of brain targeting utilizing bispecific antibodies grows rapidly, this research aims to solve critical challenges in delivering biologics to the CNS.

This position provides opportunities to develop expertise in:
1. Protein production and purification
2. Pharmacokinetics analysis using radiotracing
3. Biodistribution profiling in the brain and spinal cord using fluorescence microscopy
4. Efficacy analysis in preclinical neurodegenerative disease models
5. Delivery of gene silencing agents (ASOs and siRNAs) to the CNS

Preferred experience: Candidates with experience in biochemistry methods and animal handling (particularly mice) are of particular interest.

Interested candidates should email Dr. Tessier (ptessier@umich.edu) and include their CV and names of three references.