Job Description

Senior Research Scientist : Synthesis R&D

Purpose of the Role:

To contribute to early-stage drug discovery programs by designing and synthesizing novel small molecules that meet client objectives. The role supports hit-to-lead and lead optimization efforts through data-driven medicinal chemistry strategies, with the goal of delivering high-quality drug candidates in a collaborative CRO environment.

Key Responsibilities:

Strategic & Scientific:

• Design and synthesize novel chemical entities (NCEs) guided by SAR and target profile.
• Contribute to lead identification and optimization in FTE or integrated drug discovery (IDD) projects.
• Collaborate with cross-functional teams (e.g., biology, ADME, computational chemistry) to advance candidate selection.
• Analyze biological and ADME data to refine compound design strategies.

Operational:

• Plan and execute multistep organic syntheses with minimal supervision.
• Characterize compounds using NMR, LCMS, HPLC, and other analytical tools.
• Maintain detailed and accurate experimental records (ELN/lab notebooks).
• Deliver high-purity compounds on time to meet client/project goals.

Collaboration & Communication:

• Actively participate in team meetings, project reviews, and client discussions.
• Coordinate with analytical and biology teams for data turnaround and integration.
• Present experimental results and SAR insights to internal and external stakeholders.

Compliance & Documentation:

• Follow lab safety protocols and maintain GLP/GMP (where applicable).
• Ensure adherence to SOPs and maintain project documentation for IP protection and client reporting.

Qualification & Experience:

• M.Sc. with 3–8 years of relevant experience in a CRO environment.
• Proven expertise in synthetic organic chemistry and medicinal chemistry principles.
• Experience in client-facing discovery projects is strongly preferred.

Key Skills & Competencies:

• Deep understanding of SAR, pharmacophores, and drug-likeness criteria.
• Strong skills in synthetic planning, reaction optimization, and troubleshooting.
• Excellent communication and data presentation abilities.
• Ability to multitask and work effectively in a high-paced, collaborative environment.