Job Description

AI Proteins is a Boston-based biotechnology company focused on the de novo design and engineering of miniprotein therapeutics. We combine cutting-edge computational protein design and artificial intelligence with synthetic biology and laboratory robotics to accelerate the creation of life-changing medicines. Our common goal is to markedly improve human health and well-being. Our environment is rigorous and collaborative, bringing together passionate individuals who are making an impact. We inspire creativity by embracing an open culture that fosters initiative, teamwork, and excellence.

Position Summary:

AI Proteins is seeking a scientist with mass spectrometry hands-on experience to lead the analytical efforts for the characterization of miniproteins and bioconjugates. This role gives the opportunity to own and shape the company’s mass spectrometry strategy, from initial reliance on contract research organizations (CROs) to building a best-in-class internal analytical function with the right instrumentation, workflows, and talent to meet evolving program needs. The ideal candidate will collaborate across interdisciplinary teams, including protein engineering and manufacturing.

Responsibilities:

Areas of specific responsibility and attention will include the following:

● Develop and manage analytical tools, focusing on mass spectrometry and chromatography-based techniques to characterize unknown impurities and degradation products derived from miniprotein manufacturing.

● Design, perform and interpret LC-MS, LC/MS/MS and LC-QTOF/MS workflows to characterize miniproteins conjugates (including metal loading), ADCs drug substances, and intermediates.

● Develop workflows and analysis of LC/MS and MS based quantitation methods for miniproteins in complex matrices to support preclinical pharmacokinetic studies in collaboration with pharmacology and DMPK teams.

● Stay at the forefront of technological advancements in mass spectrometry and other analytical technologies, integrating innovative solutions to enhance current workflows

● Purchase, set-up, and maintain relevant equipment to build internal mass spectrometry capabilities based on companies needs

● Manage outsourced analytical projects with CROs, ensuring scientific quality, appropriate study design, and timely delivery of actionable data.

● Prepare internal reports, presentations, protocols and technical documents for internal use and conferences.

● Participate in internal team meetings by actively engaging in scientific and technical discussions.

Professional Experience / Qualifications:

● Ph.D., M.S., or B.S. in Biochemistry, Biotechnology, Chemistry, or related field with relevant experience in mass spectrometry, bioconjugation, or chemical biology.

We look for a strong track record of success and high technical aptitude in the development of analytical assays powered by mass spectrometry.

• For Ph.D. candidates: minimum of 1+ year of post-doctoral or industry experience in the development of mass spectrometry workflows.
• For M.S. candidates: minimum of 4+ years of experience in the development of mass spectrometry assays within a biopharmaceutical setting.
• For B.S. candidates: minimum of 6+ years of hands-on experience in biopharmaceutical settings.

● Expertise on characterization and determination of post-translational modification in recombinant proteins using LC/MS and LC/MS/MS

● Experience in characterization of bioconjugates, including metal-containing conjugates or peptide-toxin conjugates using LC/MS, LC-QTOF/MS and ICP/MS.

● Demonstrated experience supporting bioanalytical studies, including preclinical pharmacokinetic and matrix stability analyses is a must.

● Experience managing relationship with CROs is highly desirable

● Familiarity with GMP, GLP, and regulatory guidelines for biologic product development (preferable but not required)

● Proven ability to design and execute experiments, analyze complex data, and troubleshoot bioconjugation protocols.

● Strong communication and teamwork skills in a cross-functional environment.

● Strong communication skills: Effective cross-functional communicator, able to convey complex concepts and strategies, in writing and presentations; receptive to diverse input and feedback.

● Talented problem solver: Strategic problem solver, self-directed, scientifically rigorous, and capable of managing and implementing complex technical projects.

● Highly energetic: Adaptable and proactive, able to thrive in dynamic settings, respond flexibly to change, and drive progress with creativity and determination.

What we offer:

● We offer competitive salaries and a great 401k plan with matching on the first 5% of your salary. With our Incentive Units, you will own part of the company’s success

● Be part of the team that brings a groundbreaking new modality of protein-based medicine to the world

● We provide an unlimited amount of very fancy coffee – stay active but do not die

● Keep your glucose level steady with our snack bar, and choose from our unparalleled collection of salsas and hot sauces 🔥

● We are located in the heart of Fenway, surrounded by many great restaurants and entertainment opportunities.

Send your CV to: careers@aiproteins.bio

AI Proteins, Inc. provides equal employment opportunities to all employees and applicants without regard to race, color, religious creed, sex, national origin, ancestry, citizenship status, pregnancy, childbirth, physical disability, mental disability, age, military status or status as a Vietnam-era or special disabled veteran, marital status, registered domestic partner or civil union status, gender (including sex stereotyping and gender identity or expression), medical condition, genetic information or sexual orientation in accordance with applicable federal and state laws.