Job Description

HANSOH BIO

Hansoh Bio is a U.S.-based subsidiary of Hansoh Pharmaceutical Group Company Limited, a biopharma company founded in 1995. Hansoh Pharma discovers and develops breakthrough therapies for serious diseases and disorders affecting patients around the world, employing 9,000 workers and 1,400 R&D professionals. With over 40 products in commercialization, the Company’s pipeline programs and products cover therapeutic areas such as oncology, central nervous system, anti-infectives, diabetes, as well as gastrointestinal and cardiovascular diseases.

Hansoh Bio is a biotech Research and Development (R&D) arm of Hansoh Pharma based in Rockville, MD, focused on de novo drug discovery and development of novel therapeutics. Hansoh Bio is thrilled to offer exciting opportunities for researchers and scientists to engage in target discovery and pre-clinical candidate development of high impact projects, while being an integral member of a collaborative, passionate, and goal-oriented team.

For more information, please visit www.hspharm.com

Structural Biology and Biophysics – MARYLAND R&D CENTER

We are currently seeking a motivated and multi-talented scientist to join our peptide discovery and development team in Rockville, Maryland. This role will focus on the design, screening, and optimization of peptide-based ligands against biologically relevant targets. The successful candidate will contribute to the development of innovative screening platforms and drive hit-to-lead and lead optimization efforts toward preclinical candidate selection.

This position requires a strong foundation in protein–ligand interactions, peptide chemistry/biology, and a demonstrated ability to integrate experimental and computational approaches.

RESPONSIBILITIES

• Develop novel screening strategies to identify peptide binders

• Drive optimization of peptide hits for affinity, selectivity, stability, and developability

• Leveraging computational tools (e.g., molecular modeling, docking, MD simulations) to inform peptide design

• Apply structure activity relationship principles to guide iterative design cycles

• Interpret structural biology data (e.g., X-ray, cryo-EM, AlphaFold models) to guide optimization strategies

• Work closely with biophysics, structural biology, medicinal chemistry, and in vivo pharmacology teams

• Provide timely communication and presentations

REQUIREMENTS

• Ph.D. degree in biochemistry, biophysics, molecular biology or related areas with 5+ years of research experience. Post-doctoral experience is preferred but not required

• Familiarity with computational chemistry or structural modeling tools

• Strong experience in molecular biology such as RT-PCR, qPCR, etc

• Strong experience in expression, purification, and biophysical characterization of proteins

• Strong understanding of protein–ligand interactions and binding kinetics

• Hands-on experience with biophysical binding assays (SPR, BLI, ITC, etc.)

• Experience with peptide discovery platforms (e.g., phage display, mRNA display, yeast display) is preferred

• Experience in SAR-driven optimization and lead development is preferred

Requirements added by the job poster

• Doctor of Philosophy