Job Description

• Worcester, MA
• Full-time
• Salary Min: 106500
• Salary Max: 202500
• Travel: Yes, 5% of the Time
• Compensation: USD 106,500 – USD 202,500 – yearly

Company Description

AbbVie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated and experienced scientist to join the Protein Sciences Analytical Team in Worcester, MA. This position provides a unique opportunity to directly impact multiple Discovery Research Therapeutic Areas (TAs) and projects by delivering in-depth analytical and functional characterization of biologics and biopharmaceutical products—including complex protein antigens, monoclonal antibodies, multi-specifics, and other antibody-like biologics. The ideal candidate will have a strong background in protein analytical characterization, with expertise in structural mass spectrometry, including hydrogen-deuterium exchange mass spectrometry (HDX-MS), crosslinking mass spectrometry (XL-MS), and covalent labeling mass spectrometry (CL-MS) to characterize epitopes and antigen-antibody interactions. The successful candidate will foster productive collaborations across functional groups and therapeutic areas. This is an excellent opportunity for a motivated scientist to make a significant impact in a collaborative and innovative environment. Join us in bringing innovative medicines to patients!

Key Responsibilities:

• Independently develop and execute high-throughput HDX-MS workflows for epitope mapping analysis of biotherapeutics to support discovery pipeline projects.
• Develop, optimize, validate, and apply innovative structural MS methods (including XL-MS and CL-MS) to characterize epitopes and antigen-antibody interactions.
• Demonstrate scientific initiative and creativity by establishing novel workflows and strategies for the characterization and screening of biologics—including non-traditional modalities such as multi-specifics, alternative scaffolds, and fusion proteins—to support BGM and TA projects.
• Collaborate with external partners, CROs, or vendors to advance project objectives.
• Analyze, document, and report data concisely; formulate conclusions and design follow-on experiments based on multidisciplinary inputs.
• Resolve key project challenges by leveraging analytical tools, information, and technical expertise.
• Communicate project progress, data analyses, and technical recommendations clearly and promptly to cross-functional teams and senior management.
• Present original research and findings internally and at external scientific conferences; contribute to scientific papers, patents, and technical reports as an author or co-author.

Qualifications

• BS or MS or PhD in biology, chemistry, biochemistry or related field with typically 10-12+ (BS), 8-10+ (MS) or 0-4+ (PhD) years of experience.
• Extensive hands-on experience with HDX-MS platforms (e.g., Trajan’s LEAP HDX automation) and use of HDX-MS data analysis software (e.g., HDExaminer) for epitope mapping analysis.
• Strong knowledge of structural mass spectrometry technologies, including covalent labeling MS, and crosslinking MS.
• Advanced proficiency with multiple mass spectrometry platforms (such as Orbitrap and Q-ToF), including MS workflows for protein characterization and expertise with relevant data analysis software.
• Familiarity or experience with coding/programming (e.g., Python, R, or relevant scripting languages) and in developing automated data workflows or solutions is preferred.
• Familiarity with biophysical and structural methods, such as DLS, DSF, SEC-MALS, SEC-SAX, X-ray crystallography, etc. is a plus 
• Demonstrated theoretical and hands-on expertise in scientific disciplines, with a proven ability to rapidly learn and apply new technologies.
• Excellent organizational skills and ability to manage multiple projects and tasks concurrently while meeting deadlines.
• Collaborative, goal-driven professional with strong verbal and written communication skills, a proactive attitude, and success operating in fast-paced, cross-functional environments.

Key AbbVie Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
• Learns fast, grasps the “essence” and can change course quickly when indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Position will be filled at level commensurate with extent of education, experience, and accomplishment – Senior Scientist I or Senior Scientist II

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
• This job is eligible to participate in our short-term incentive programs. ​
• This job may be eligible to participate in our long-term incentive programs​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html