Job Description

The Polymer Process Chemist will play a central role in scaling chemical processing and materials purification activities from discovery laboratory scale to manufacturing scale. This individual will act as a critical liaison between Endomedix and an external Contract Development and Manufacturing Organization (CDMO), ensuring the successful transfer and scale-up of processes, purification steps, and analytical control methods.

Post-scale-up, the chemist will support the development of a Good Laboratory Practice (GLP; 21 CFR §58)-compliant quality system to enable production of materials for nonclinical and clinical testing. Additional responsibilities include development of sterilization methods, stability assessments, internal synthesis and purification of polysaccharides, and ownership of analytical methodologies.

II. Duties and Responsibilities

• Perform chemical synthesis of derivatized natural polymers using established SOPs.
• Conduct purification processes of polymers per standardized procedures.
• Coordinate with external laboratories conducting H-NMR and SEC-MALS analyses.
• Perform instrument calibrations and materials preparation for laboratory operations.
• Review CDMO procedures to ensure accurate translation of Company protocols and identify potential risks or issues.
• Assist in the development of CDMO work plans and schedules.
• Analyze CDMO test batch results using data from SEC-MALS, SEC-RI, H-NMR, FTIR, UV, and titration methods.
• Review process control data from the CDMO to identify trends and quality metrics.
• Perform QC verification of conformity with SOP for every batch
• Conduct in-house batch testing including:
• Mechanical testing
• Titrations
• SEM imaging
• Viscosity analysis using rheometry
• Support sterilization method development for Endomedix proprietary materials
• Follow and help refine SOPs for established lab techniques.
• Perform statistical analysis on internal and CDMO batch records.
• Assist with the preparation of grant proposals and technical reports.

III. Supervisory Responsibilities

• None

IV. Qualifications

• Ph.D. in organic chemistry, polymer chemistry, material science, or biomedical engineering
• (Must have graduated within the past 12 months or be graduating within the next 12 months)
• 3+ years hands-on experience with organic/polymer synthesis required
• (Experience with polysaccharides strongly preferred)
• Extensive experience with polymer characterization techniques, including:
• GPC/SEC
• Viscometry
• Rheology
• Demonstrated ability to troubleshoot and solve complex problems in polymer chemistry and scale-up.
• Strong understanding of structure-property relationships in polymers.
• Proficiency in bench-scale wet chemistry and spectroscopy (NMR, FTIR).
• Prior lab-based chemical synthesis or analytical/product development experience required.
• Experience using statistical analysis for data-driven decision making.
• Willingness to travel between CDMO site and company location as needed.

Additional Information

• Salary: Commensurate with experience
• Eligibility: U.S. Citizens or Green Card holders only