Job Description

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, entered clinical trials in late 2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of ~50 FTEs in R&D, business development, people & culture, finance and operations. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor.

We’re hiring a Scientist orSenior Scientist to join our collaborative Translational Sciences team focused on designing and advancing first-in-class immune-engaging biologics. This is a hands-on, lab-based role where your contributions directly shape the next generation of immunotherapy.

We value curiosity, collaboration, and diverse perspectives—if you’re excited by our mission but unsure if you meet every requirement, we encourage you to apply.

What You’ll Work On

• Design and conduct in vitro studies with an emphasis on immunological testing of human and animal samples using state-of-the-art techniques, including immune cell functional assays, multi-parameter flow cytometry, cell separation, multiplex assays, cell toxicity, and proliferation assays
• Maintain records of experiments in electronic notebooks, analyze data, and prepare presentations with strong attention to detail
• Partner with immunobiology, biotherapeutics, and in vivo pharmacology teams to ensure proactive sharing of scientific know-how across the organization
• Provide scientific input to optimize project progression
• Deliver clear, concise presentations at portfolio and project meetings to enable organizational alignment
• Support the authoring of essential internal and regulatory documents
• Ensure compliance with all health and safety protocols

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What You Bring

• Ph.D. in immunology or a related field with 0-3 years of postdoctoral or industry experience
• Experience with immunology, biochemistry, and molecular methods (e.g., multicolor flow cytometry to phenotype diverse populations; PBMC and purified primary immune cell functional assays; proteomic analysis using multiplex assay such as MSD, Luminex; western blot analysis; mRNA analysis)
• Evidence of a track record of scientific and project achievements
• Capable of clarifying problems and working in collaboration with team members to identify solutions
• Ability to independently design and execute research plans for one or more programs and to rapidly review, analyze, and interpret experimental results
• Ability to follow protocols and directions
• Data analysis experience with GraphPad Prism and general knowledge of routine statistical analysis
• Strong verbal and written communication skills
• Experience in bioinformatics is a plus

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What You’ll Gain

• A high-impact opportunity to help advance novel biologic therapies targeting solid tumors
• Mentorship and guidance to support your professional growth in translational immunology and drug development
• Exposure to integrated drug discovery across immunobiology, protein engineering, in vivo models, and translational research
• A mission-driven environment where your contributions matter and discovery meets real-world impact

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Why You’ll Love Working Here

• Direct impact: Your science will influence platform design and shape next-generation clinical programs.
• Cutting-edge science: Help pioneer new approaches to T cell redirection in solid tumors.
• Personal growth: Gain exposure to every stage of early discovery in a collaborative biotech setting.
• Collaborative culture: Join a supportive, curious, and driven team aligned around scientific innovation and patient outcomes.
• Top-tier facilities: Work in a brand-new, purpose-built lab and office space near New Haven, CT.
• Mission with meaning: Join a company working to give more patients real hope in the fight against cancer.

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Additional Info

• This is a full-time, onsite position based in Branford, CT
• EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered
• We offer competitive salary, benefits, equity, and paid time off
• We are an equal opportunity employer and value diverse perspectives in all aspects of our work
• Learn more about our science and our team at www.evolveimmune.com