Job Description

AI Proteins is a Boston-based biotechnology company focused on the de novo design and engineering of miniprotein therapeutics. We combine cutting-edge computational protein design and artificial intelligence with synthetic biology and laboratory robotics to accelerate the creation of life-changing medicines. Our common goal is to markedly improve human health and well-being. Our environment is rigorous and collaborative, bringing together passionate individuals who are making an impact. We inspire creativity by embracing an open culture that fosters initiative, teamwork, and excellence.

Position Summary

We are seeking a highly motivated Senior Research Associate to join our Protein Characterization team. This team plays a key role in advancing our drug development pipeline, partnering with project leaders from early discovery through candidate selection. The role focuses on evaluating developability risks and pharmacokinetic (PK) properties of miniprotein drugs to enable progression of drug candidates into early development. The ideal candidate will have strong expertise in protein biochemistry, hands-on experience with biophysical and biochemical assays, and the ability to collaborate effectively across teams.

Responsibilities

• Develop and execute assays to assess the developability of miniprotein therapeutics, generating high-quality data to identify drug liabilities and prioritize candidates that meet project design goals.
• Design and execute pharmacokinetic (PK)-enabling assays, including plasma protein binding, biological matrix stability assessments, and bioanalytical method development.
• Leverage protein biochemistry expertise to interpret complex datasets and guide engineering strategies that improve stability, manufacturability, and overall therapeutic potential.
• Maintain meticulous records, analyze data, interpret results, and present findings at project meetings.
• Collaborate closely with cross functional teams.

Qualifications

• Bachelor’s degree with ≥2 years of biotech/pharma experience, or a Thesis-based Master of Science degree in Biochemistry, Chemical Biology, or a related field.
• Strong hands-on experience in protein biochemistry and the ability to design, execute, and interpret experiments that drive therapeutic development.
• Proficiency in protein characterization techniques (DLS, HIC, SEC, CD, etc.)
• Experience assessing protein developability (thermal stability, solubility, protease resistance) and developing high-throughput assays to accelerate candidate prioritization.
• Familiarity with Biomek/Hamilton liquid handlers and experience working with small proteins (<10 kDa) is a plus.
• Ability to work independently, manage priorities effectively, contribute to a collaborative team, and communicate complex data clearly to diverse audiences.

What we offer

• We offer competitive salaries and a great 401k plan with matching on the first 5% of your salary. With our Incentive Units, you will own part of the company’s success 
• Be part of the team that brings a groundbreaking new modality of protein-based medicine to the world
• We provide an unlimited amount of very fancy coffee – stay active but do not die
• Keep your glucose level steady with our snack bar, and choose from our unparalleled collection of salsas and hot sauces 🔥
• We are located in the heart of Fenway, surrounded by many great restaurants and entertainment opportunities

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AI Proteins, Inc. provides equal employment opportunities to all employees and applicants without regard to race, color, religious creed, sex, national origin, ancestry, citizenship status, pregnancy, childbirth, physical disability, mental disability, age, military status or status as a Vietnam-era or special disabled veteran, marital status, registered domestic partner or civil union status, gender (including sex stereotyping and gender identity or expression), medical condition, genetic information or sexual orientation in accordance with applicable federal and state laws.

Email Us to Apply

Please email your CV to careers@aiproteins.com and include the Job ID 

AIP-JobID-11F

 in your email. We look forward to hearing from you.