Job Description

Application Deadline : 18 November 2025 23:59:00 Paris time

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General information

Offer title : Fixed-term contract researcher (M/F) Structure-function of GPCRs (H/F)
Reference : UMR5203-GUILEB-006
Number of position : 1
Workplace : MONTPELLIER
Date of publication : 28 October 2025
Type of Contract : Researcher in FTC
Contract Period : 24 months
Expected date of employment : 9 February 2026
Proportion of work : Full Time
Remuneration : from 3071.50€ gross per month, depending on experience.
Desired level of education : Doctorate
Experience required : Indifferent
Section(s) CN : 01 – Interactions, particles, nuclei, from laboratory to cosmos

Missions

The main task of the successful candidate will be to study G protein-coupled receptor (GPCR) signaling complexes and the modulation of their functions using cell culture approaches, membrane protein biochemistry, mass spectrometry, and cryogenic electron microscopy (cryoEM).

Activities

Expression of RCPGs in eukaryotic cell lines
Manipulation of lentivirus and AAV viruses for RCPG expression
Analysis of the protein composition of signaling complexes in cells by mass spectrometry.
Structural study of signaling complexes using mass spectrometry under native conditions.
Expression and purification of receptors and their signaling complexes
SIngle particle cryoEM, 3D reconstruction, and model construction.
Analysis of 3D structures and presentation of results.

Skills

Ability to maintain cell lines in culture, differentiation of precursors into macrophages (BMDM), cell culture in suspension.
Biochemistry of membrane proteins.
Ability to prepare and observe samples for fluorescence/electron microscopy.
Ability to process microscopy data, image analysis, 3D reconstruction, 3D model construction.
Ability to write and present scientific data in a rigorous manner.
Ability to interact effectively with the various scientific stakeholders in the project.

Work Context

The Functional Genomics Institute is a joint research unit comprising 330 people and 23 teams working in the fields of neuroscience, physiology, and cancer, and hosting seven technical platforms (genomics, proteomics, pharmacological screening, vectorology, small animal imaging, functional exploration). The Functional Genomics Institute (IGF) is renowned for its extensive work on GPCRs and on understanding neurological systems. The successful candidate will join the team led by Guillaume Lebon and Cyril Goudet, whose work focuses on studying the structural and molecular bases of neuromodulation. The candidate will work under the supervision of Guillaume Lebon as part of a collaborative project funded by the French National Research Agency. We have access to the electron microscopy platform hosted at the Structural Biology Center, which will soon be equipped with a FIB-SEM and a 200 kV TEM, with installation planned by the end of 2025. “The IGF is located on the Arnaud de Villeneuve campus, which is part of the Objectif Employeur Pro-Vélo program.”